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Author

Malvina Papanastasiou

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Open access Oct 2026

Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen

SUMMARY Acanthamoeba castellanii causes infectious blindness and is a key evolutionary outgroup to humans and fungi. Its divergent mitochondria are of outstanding interest due to predicted aerobic and anaerobic functions with potential for drug targeting. However, a detailed delineation of its bioenergetic machinery, t...

Jonathan A. Stefely, Felicia Deng, Michael Z. Chen et al. · 6 citations
Open access Oct 2026

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites

SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...

Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al. · 2 citations
Open access Aug 2026

Seed-Guided De Novo Design Expands the Structural Diversity of Antitoxin Protein Binders

These results establish motif scaffolding of surface-complementing seeds as an effective strategy for overcoming current limitations of de novo generative models, enabling the design of proteins that can engage challenging interface sites.

D. Britton, Dia A. Ghose, J. Halpin et al. · 0 citations

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