Author

Mamdouh F. A. Mohamed

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Review Open access Oct 2026

1,3,4-Oxadiazole–sulfonamide hybrids: recent advances in biological activities, structure–activity relationships, and therapeutic applications

The available evidence demonstrates the remarkable therapeutic versatility of 1,3,4-oxadiazole–sulfonamide hybrids and supports their continued exploration as promising scaffolds for future drug discovery and development.

Alshaimaa Hosney, Elshimaa M. N. Abdelhafez, Mamdouh F. A. Mohamed · RSC Advances · 0 citations

Open access Sep 2026

Rationale design and synthesis of new quinazoline derivatives as DNA intercalators and topoisomerase II inhibitors.

Results underscore the therapeutic potential of VIIIe and its analogs as promising lead candidates for the development of selective, DNA-targeted anticancer agents.

Amr S. Helmy, Mamdouh F. A. Mohamed, I. Eissa et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

Exploration of novel hydroxamic acid-based candidates integrating chalcone scaffold cap as multitarget HDAC inhibitors: design, anti-prostatic cancer assessment, in silico docking and molecular dynamic simulation

The potential use of this compound for treating prostate cancer with bone metastasis is suggested, as its high affinity for HDACs and an atomistic standard 100 ns dynamic simulation supported the stability of these interactions.

Aya I. Abd El-hameed, Ibrahim M. Salem, Rasha M. Allam et al. · Journal of Enzyme Inhibition... · 1 citation