Ma’mon M. Hatmal

Decoding MLK4 Inhibition with Interpretable Machine Learning: Identification of a Novel Dihydroimidazopyridine-Based Promising Lead Compound

These findings introduce H_1 as a computationally prioritized, putative MLK4-binding lead and provide a hypothesis-generating framework for MLK4-targeted scaffold prioritization, while recognizing that experimental activity and kinome selectivity profiling remain necessary before H_1 can be described as a confirmed MLK4 inhibitor or MLK4-selective compound.