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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Man-Jeong Paik

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Open access Sep 2026

Discovery of tricyclic benzo[4,5]imidazo[2,1-b]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

A series of 13 novel 3-hydroxyindolin-2-one-benzo[4,5]imidazo[2,1-b]thiazole hybrids was designed, synthesized, and evaluated as potential anti-Alzheimer agents targeting monoamine oxidase B (MAO-B) and cholinesterases. The target compounds were obtained by condensing a benzo[4,5]imidazo[2,1-b]thiazole-based ketone wit...

Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim et al. · 0 citations
Open access Sep 2026

Single Tire-Derived Pollutant (6-PPD) Exposure Triggers Lung Injury and Mitochondrial Disruption in Mice.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6-PPD) is a widely used tire antiozonant that has recently emerged as a global environmental concern. Although its aquatic toxicity is well documented, its respiratory toxicity in mammals remains poorly understood. We aimed to characterize the temporal progression of...

Je-Hein Kim, Min-Sung Kang, Ju-Hong Lee et al. · 0 citations
Open access Sep 2026

AI-assisted metabolomic profiling identifies candidate metabolites associated with diabetic kidney disease staging in a Korean cohort

Summary Diabetic kidney disease (DKD) is commonly staged using albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR), yet complementary molecular markers are needed. We profiled urine and serum metabolites from 92 Korean participants (72 with type 2 diabetes and 20 healthy controls) using ga...

Inha Jung, Sungjin Park, Moongi Ji et al. · 0 citations
Open access Aug 2026

Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity

A new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronou...

Wagdy M. Eldehna, Ashraf K El-Damasy, Jaeyeop Lim et al. · 1 citation
Open access Sep 2026

Inotodiol prevents age-related muscle wasting by restoring mitochondrial function through liver X receptor beta signaling

Ino treatment significantly improved muscle mass and function in aged mice and prevented dexamethasone (DEX)-induced muscle atrophy and is identified as a promising therapeutic candidate for preserving mitochondrial function and alleviating age-associated muscle dysfunction.

Chang-Lim You, Ju-Hyeon Bae, Yideul Jeong et al. · 0 citations
Open access Aug 2026

Meloxicam protects against muscle and metabolic decline in ageing through Cdon restoration and oxidative stress modulation

Meloxicam (Mcam) is identified as a small molecule inducer of Cdon that enhances myogenic differentiation, increases muscle mass and function in young mice and mitigates age-related muscle atrophy, and is identified as a potential therapeutic target for age-associated skeletal muscle degeneration.

Ju-Hyeon Bae, Hyun-Kyung So, Yideul Jeong et al. · 0 citations

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