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MAPK3 as a ferroptosis driver in excitatory neurons in Alzheimer’s disease: from genetic causal inference to in vivo functional validation
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and ferroptosis-an iron-dependent form of regulated cell death-has been increasingly implicated in AD-related neuronal loss. However, the causal relationship between specific ferroptosis-related genes and AD, particularly within defined...