Association of peripheral TLR9 gene expression with renal function and inflammatory cytokine profile in chronic kidney disease: A case-control study.
BACKGROUND Chronic kidney disease (CKD) involves persistent low-grade inflammation that perpetuates kidney injury. Toll-like receptor 9 (TLR9), an innate-immune sensor of unmethylated CpG and mitochondrial DNA, may contribute to this process, but its peripheral-blood expression in CKD remains unclear. METHODS In a cr...