Imported falciparum malaria remains an important challenge in China, particularly with the emergence of antimalarial resistance in Africa. This study characterized resistance-associated mutations in pfk13, pfcrt and pfmdr1 by nested PCR and Sanger sequencing of 291 Plasmodium falciparum (P. falciparum) isolates importe...
Li-Jun Chen, Qiang Mao, De Wu et al.· Pathogens· 0 citations
ABSTRACT Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel comparison of three mNGS libra...
Geng-Yan Luo, Jin Zhao, Lin-Lin Xie et al.· mSystems· 0 citations
Individual-organ RNA sequencing can complement conventional parasitology and help prioritize widespread or unusual lineages for taxonomic, ecological, and public-health investigation and establish individual-organ metatranscriptomics as a useful framework for parasite discovery and surveillance.
Min-wu Peng, De Wu, Qing-Quan Cen et al.· bioRxiv· 0 citations
This study conducted a nationwide single-mosquito meta-transcriptomic survey of 5,163 mosquitoes representing 100 species across China, integrating viral discovery with marker-gene profiling of bacteria, archaea, fungi, and other eukaryotic microbes to establish a detailed view of the full-spectrum microbiome.
Qin-yu Gou, Wei-Chen Wu, Pei-Bo Shi et al.· bioRxiv· 0 citations
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