Open access
Sep 2026
Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity
Investigation of how neuronal ERO1L elevation reshapes cellular homeostasis before overt dysfunction in Drosophila melanogaster establishes a pre-symptomatic state in which proteostatic and metabolic adaptation coexists with early vulnerability of nuclear and RNA-homeostasis pathways, preceding overt oxidative stress a...
L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al.
· bioRxiv · 0 citations