Author

Manish Goyal

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Open access Oct 2026

A high-confidence inventory of the proteins in the mitochondrion-related organelle of Giardia

SUMMARY Giardia lamblia is a microaerophilic protozoan parasite that infects nearly 280 million people worldwide each year. Giardia lacks a mitochondrial genome and mitochondrial enzymes for oxidative phosphorylation. However, it retains mitochondrion-related organelles (MROs) that house an iron-sulfur cluster (ISC) as...

Manish Goyal, Tiana M. Issa, Jonathan A. Stefely et al. · Current Biology · 2 citations

Open access Oct 2026

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites

SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...

Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al. · Molecules and Cells · 2 citations