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Author

Manish Kumar

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Open access Sep 2026

Integrated In Silico Analysis Reveals ABC Transporter ATP-Binding Protein as a Therapeutic Target in Helicobacter pylori

Helicobacter pylori remains a major cause of gastric diseases, while increasing antimicrobial resistance highlights the need for novel therapeutic targets. Here, we developed a comprehensive computational target-prioritization framework integrating Rosetta Stone domain-fusion analysis, subtractive genomics, metabolic...

Manish Kumar, Hulikal Shivashankar Santosh kumar, B. Kumar et al. · 0 citations
Aug 2026

Targeting methyl-accepting chemotaxis transmembrane sensory protein inhibits Helicobacter pylori autoinducer-2 quorum sensing system

Findings suggest that Withaferin A and Obacunone could serve as promising therapeutic agents against H. pylori infections by disrupting quorum sensing and biofilm formation, thus addressing the challenge of antibiotic resistance in this pathogen.

Thejaswi Bhat, Manish Kumar, T. Gnanasekaran et al. · 0 citations

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