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Author

Manish R. Bhise

2 papers indexed here

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Review Sep 2026

Advances in Novel Drug Delivery Systems for Targeting the Brain: Overcoming Barriers and Enhancing Therapeutic Efficacy.

The blood-brain barrier (BBB) is critical in CNS pharmacotherapy; it blocks the entry of 98 per cent of small-molecule compounds and almost all macromolecules into the brain parenchyma via tight junction complexes, efflux transporter action, and enzymatic breakdown. This review focuses on the mechanistic basis of BBB r...

Manish R. Bhise, K. Thejomoorthy, Mohit Kumar et al. · 0 citations
Open access Aug 2026

Design, Molecular Docking and Neuroprotective Screening of Novel Pyrimidine-Based Acetylcholinesterase Inhibitors

Alzheimer's disease (AD) remains a multifactorial neurodegenerative disorder and currently there are only a few symptomatic therapies available to treat the cholinergic system. The pyrimidine scaffold has become a privileged scaffold for the design of multi-target directed ligands (MTDLs) that are effective at targetin...

Salahuddin S, Lovely Lovely, Mukesh Kumar Singh et al. · 0 citations

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