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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Manojkumar Venkatesan

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Open access Sep 2026

Model-Informed Population Pharmacokinetic Simulation of Osimertinib and Az5104 in a Virtual Indian Nsclc Cohort: Exposure Variability, QTCF Tail-Risk Quantification, and Risk-Stratified ECG Monitoring

Objective: Osimertinib is a third generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that has concentration-dependent QTc prolongation. Pivotal trials are under-representing Indian patients and they could differ in specific baseline characteristics (covariates) that are important for drug...

Manojkumar Venkatesan, Dhivya Dhanasekaran, D. M et al. · 0 citations

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