Author

Manon A. A. Jansen

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Open access Sep 2026

Knowledge and Self-Efficacy Regarding Traumatic Dental Injury Management Among Dutch Dentists: A Cross-Sectional Study.

INTRODUCTION AND AIMS Traumatic dental injuries (TDIs) represent a significant number of oral region injuries. Despite existing guidelines, studies suggest dentists have insufficient knowledge of TDI management. This cross-sectional study aimed to assess knowledge and self-efficacy regarding TDI management among a samp...

Manon A. A. Jansen, A. C. Georgiou, A. Baaij · International Dental Journal · 0 citations

Clinical trial Open access Aug 2026

IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

Low-dose interleukin-2 (IL-2) shows potential for treating autoimmune disorders by expanding regulatory T cells (Treg), but therapeutic utility is limited by short half-life and off-target effects. Here, we describe the molecular design, nonclinical development, and first-in-human study of MHS552, an IL-2 mutein-engraf...

Igor Radanović, Michael DiDonato, A. Meijs et al. · Nature Communications · 0 citations