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Author

Manuel Collado

2 papers indexed here

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Open access Sep 2026

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Cellular senescence exerts powerful non‐cell autonomous effects through the senescence‐associated secretory phenotype (SASP). This SASP comprises soluble factors and extracellular vesicles (EVs). Although soluble SASP components can induce senescence in neighboring cells, the specific contribution of EVs to paracrine s...

Valentín Estévez-Souto, Alex Miralles-Domínguez, Pablo Pedrosa et al. · 0 citations
Open access Feb 2026

Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells.

BACKGROUND Spatially fractionated radiotherapy (SFRT) is an emerging therapeutic strategy that enhances tumor control while reducing normal tissue toxicity. Although conventional radiotherapy is known to induce therapy-induced senescence (TIS), its induction by SFRT-particularly mini-GRID radiotherapy-remains poorly ch...

M. Acuña, M. Prados, S. Da Silva-Álvarez et al. · 0 citations

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