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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Manuel Hertwig

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Open access Aug 2026

Activity-based chemical proteomics uncovers unexpected covalent targets of E64d and reveals a role for cysteine cathepsins in PLD3 proteostasis

In neurons, treatment with E64d lead to about 50-fold PLD3 accumulation and dysregulation of its proteolytic cleavage, while there was only a minor overall change on the whole proteome level, which suggests that their activation might be responsible for decreased PLD3 levels in neurons of patients with Alzheimer’s diseases.

Manuel Hertwig, P. Kielkowski · 0 citations

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