Hemicyanine-Based Wash-Free Near-Infrared Fluorescent Probe for Imaging Amyloid-β Aggregates in Alzheimer’s Disease
By fine-tuning the amphiphilicity of a hemicyanine scaffold to place its log P within the appropriate range, P3 is identified as a wash-free NIRF probe for Aβ aggregates and provides a wash-free, high-affinity NIRF probe for Aβ imaging.