Mara R Lanis

Investigating Cytotoxic Function in CD4+ T-cells for Cancer Immunotherapy 2260082

T-cell-based immunotherapies like ACT have mostly focused on CD8 T cells, but cytotoxic CD4 T cells (CD4 CTLs) are increasingly recognized as contributors to anti-tumor immunity. As such, we created a CD4 T-cell activating nanoparticle platform, termed the artificial antigen presenting cell (aAPC). Under Th1-skew...