Marcella Cipelli

Butyrate improves the metabolism of proximal tubular cells and attenuates tissue damage in oxalate-induced acute kidney injury.

Metabolic reprogramming of renal cells is closely linked to kidney injury and repair. In proximal tubular cells (PTCs), impaired mitochondrial and peroxisomal fatty acid oxidation leads to compensatory increase in glycolysis to meet energy demands. Short-chain fatty acids such as butyrate modulate cell metabolism and c...

Innate Lymphoid Cells and diet: the multitask cells in metabolic syndrome progression.

This review critically summarizes mainly experimental and preclinical evidence linking dietary components, gut microbiota-derived metabolites, and ILC subsets to obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and related metabolic complications.

HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

Kidney Health in a Changing Climate: Emerging Disease Patterns and Driving Mechanisms.

Climate change has reshaped global health in unprecedented ways, with CKD increasingly recognized as a major climate-sensitive condition. Kidney diseases affect an estimated 850 million people worldwide, and countries with the highest incidence are often facing rapid social and economic vulnerability alongside sustaine...