Open access
Jul 2026
Dopamine D3 receptor blockade restores hippocampal synaptic plasticity and rescues memory deficits in Alzheimer's disease mouse models
Findings demonstrate that D3R-targeting compounds rescue synaptic plasticity and memory deficits in two mechanistically distinct AD models and highlights D3R modulation as a relevant pathway for further investigation in AD-related cognitive impairment.
Maria Rosaria Tropea, Giuseppe Aceto, R. Trovato et al.
· Frontiers in Aging Neuroscie... · 0 citations