Open access
Oct 2026
Combination of Organoselenium-Loaded Nanoparticles and Conventional Chemotherapeutics Synergistically Enhances Antitumor Efficacy and Modulates Multidrug Resistance: An In Vitro Study
Background/Objectives: Cancer causes high premature death worldwide, with 35 million new cases expected by 2050. Multidrug resistance (MDR), driven by genetic and epigenetic changes, hampers chemotherapy. In this study, polymeric nanoparticles (NPs) were formulated with an organoselenium nucleoside analogue (AFAT-Se) t...
Bruna Fracari Do Nascimento, Bianca Costa Maia-do-Amaral, Taís Baldissera Pieta et al.
· Future Pharmacology · 0 citations