Open access
Aug 2026
Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA
It is demonstrated that Sam68 is required for proper expression of Polq, the gene encoding polymerase theta (Polθ), the central factor in TMEJ; loss of Sam68 results in reduced TMEJ at CRISPR-induced DSBs.
Marloes D. van Wezel, H. Kool, D. van den Heuvel et al.
· Nucleic Acids Research · 0 citations