Open access
Sep 2026
Cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK channels
The TREK two-pore domain potassium channels regulate membrane excitability and respond to diverse physiological stimuli. Single-site mutations of TREK are associated with neurodevelopmental disorders and can cause pathological channel hyperactivation. Here, using the OneOPES enhanced-sampling molecular dynamics frame...
Berke Türkaydin, Valerio Rizzi, Chaimae Benkerdagh et al.
· Nature Communications · 0 citations