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M. Scotti

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Review Open access Jul 2026

From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior

Experimental findings obtained from animal, cellular, and computational platforms further support the emergence of integrated therapeutic strategies targeting multiple neuroimmune pathways and reinforce the concept that neuroinflammation represents a central biological interface linking xenobiotic exposure to depressiv...

Alissa Maria de Oliveira Martins, Maxsyara Felismino da Silva Soares, Lucas Nóbrega de Oliveira et al. · 0 citations
Review Open access Jun 2026

Neuroinflammation in Epilepsy: Biochemical and Molecular Mechanisms and Implications for Natural Product-Driven Drug Discovery

The role of the main inflammatory targets (Inflammasome/NLRP3, NF-κB, MAPK, mTOR, COX-2/PGE2, and TLR4/HMGB1) to epilepsy is related and natural products acting through these pathways in the treatment of epileptic seizures are investigated.

A. L. Dias, P. R. da Silva, L. R. P. Souza et al. · 0 citations

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