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Author

Maren Hackenberg

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Open access Jul 2026

Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.

Accurate identification of CRISPR-Cas9 off-target sites is essential for the safety assessment of genome-editing-based therapies. While numerous in silico prediction tools have been developed, their comparative performance and practical utility in preclinical workflows remain incompletely defined. We performed a system...

M. M. Kaufmann, Maren Hackenberg, William Jobson Pargeter et al. · 0 citations

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