Author

Margery G. Smelkinson

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Open access Oct 2026

IL-2-Producing Tfh Cells Sustain Treg Cell Homeostasis and Immune Tolerance in the Gut

Follicular helper T (TFH) cells are well known for their role in supporting B cell responses. Here, we identify a critical B cell-independent function for TFH cells in sustaining regulatory T (Treg) cells within gut-associated lymphoid tissues (GALT). We demonstrate that TFH cells produce interleukin-2 (IL-2) at the T...

Shivangi Dave, Holly Bachus, Nathan Santiago et al. · Nature Immunology · 1 citation

Open access Oct 2026

Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure.

Controlling hyperlipidemia has reduced but not eliminated atherosclerotic cardiovascular disease (ASCVD) as a major cause of human mortality. Here, we report that loss of the immunoregulatory gene GTPase of immunity-associated protein 6 (Gimap6) in mice causes an inflammatory vasculopathy and accelerated atherosclerosi...

Chen Xiang, Kaja Arusha, Danielle A. Springer et al. · Cell · 0 citations

Jul 2026

Dietary exposure modulates cutaneous immunity and microbiota to facilitate wound healing 2308096

The ketogenic diet (KD), a diet enriched in fats and low in carbohydrates, feeding reshapes the metabolic environment of the skin and enhances both the abundance and metabolic output of the commensal Staphylococcus epidermidis.

Motoyoshi Nagai, Victor Band, Liang Chi et al. · Journal of Immunology · 0 citations