Open access
Sep 2026
Microglial dectin-1/Clec7a in an alzheimer’s disease model: a double-edged sword across the lifespan
Introduction Dectin-1, encoded by Clec7a, is highly expressed in disease-associated microglia in Alzheimer’s disease (AD), yet its in vivo function remains largely unknown. Methods We generated Clec7a-floxed mice and conditionally deleted dectin-1 in microglia to determine its effects on pathology and behavior using th...
Wen-Tin Xi, R. Rodriguiz, William C. Wetsel et al.
· Frontiers in Immunology · 0 citations