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Author

María Fernández-Casañas

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2 papers indexed here

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Review Open access Sep 2026

Detecting replication-associated single-stranded DNA.

Single-stranded DNA (ssDNA) is used as a readout of replication stress, yet it arises in several contexts. It is a normal intermediate of DNA replication but can accumulate and persist after replication challenges and is also generated by replication-independent processes. These structures differ in strand origin, arch...

María Fernández-Casañas, Ellie M. Wright, Gideon Coster · 0 citations
Open access Sep 2026

Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges

The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (UFBs). We reveal that...

U. Aliyaskarova, Özgün Özer, Mahafuzul Sumon et al. · 0 citations

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