Open access
Sep 2026
Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease
ABSTRACT Tau aggregation is a central pathological feature of Alzheimer's disease, yet how different forms of tau—ranging from monomers to small soluble aggregates and mature fibrils—interact with the cellular environment remains poorly understood. Here, we combine immunoaffinity proteomics with single‐molecule techniq...
Dorothea Boeken, Paula Beltran Lobo, Yun-Zhao Wu et al.
· Advancement of science · 0 citations