Open access
Sep 2026
Prenatal Δ9-tetrahydrocannabinol exposure rewires glucocorticoid-hippocampal crosstalk and impairs memory under stress in adolescent rat offspring.
BACKGROUND Stress is a major determinant of psychopathology in which coping and cognitive impairment arise from abnormal glucocorticoid activity and brain derived neurotrophic factor (BDNF)-dependent neuroplasticity in the hippocampus. The endocannabinoid system modulates stress and hippocampal functioning since early...
A. Brancato, Martina Cicero, V. Castelli et al.
· European Journal of Pharmaco... · 0 citations