Open access
Aug 2026
The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome Organization
This work shows that the germline-specific CTCFL (BORIS) is aberrantly activated in high-grade serous ovarian carcinoma, where it remodels transcriptional, epigenetic, and three-dimensional genome organization by occupying CTCF-bound chromatin loop anchors and weakening CTCF-mediated chromatin insulation.
D. N. Bhatt, Arielle Scott, Ludmila Krymskaya et al.
· bioRxiv · 0 citations