The Kynurenine Pathway as a Mediator Between Childhood Adversity and Suicidal Ideation in Adults with Major Depressive Disorder: A Proposed Clinical Study Protocol
Introduction: Childhood adversity (CA) is widely recognized as a major risk factor for adult suicidal ideation (SI). Chronic inflammation is frequently proposed as a potential mechanism, although the precise biological pathway that may contribute to SI remains unclear. The kynurenine pathway (KP) becomes activated in r...