Author

Marian Kalocsay

2 papers indexed here

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Sep 2026

Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.

Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration-approved therapy directly targets fibrotic remodeling in the heart. To address this unmet clinical need, we used a multidimensional drug discovery pipeline centered on a human induced pluripotent stem cel...

Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al. · Science · 0 citations

Open access Sep 2026

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

Beta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has been studied primarily in monomeric family A GPCRs. Here we develop...

Dagan C. Marx, Alberto J. Gonzalez-Hernandez, Joon Lee et al. · Nature Communications · 1 citation