Review
Open access
Sep 2026
Opportunities in cancer gene therapy: inhibiting MDM2 and restoring p14ARF as a means to activate p53.
The MDM2/p53/p14ARF axis represents a central regulatory network controlling cell-cycle progression, genomic stability, and tumor suppression, and is frequently deregulated in human cancers. In many malignancies, particularly those retaining wild-type TP53, p53 activity is functionally suppressed through MDM2 overexpre...
S. B. de Oliveira, A. L. V. Alves, Bianca Naomi Niitsuma et al.
· Molecular and Cellular Bioch... · 0 citations