Author

Mariana Roesch-Ely

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Open access Aug 2026

Hydroxyhydroquinone as a novel modulator of mitochondrial metabolism with potential to restore CoQ10 homeostasis.

Mitochondrial dysfunction is a hallmark of diverse metabolic and neurodegenerative disorders, often linked to impaired coenzyme Q10 (CoQ10) homeostasis. Here, we have evaluated the activity of hydroxyhydroquinone (HHQ) as a novel modulator of mitochondrial metabolism. Molecular simulations revealed that HHQ can act as...

P. R. D. Dos Santos, Joseph Rastegar, Mariana Roesch-Ely · Molecular and Cellular Bioch... · 0 citations

Open access Aug 2026

Phenolic-rich aqueous extract of connarus suberosus improves hyperglycaemia and metabolic alterations in streptozotocin-induced diabetic rats.

AIMS To chemically characterise a phenolic-rich aqueous extract of Connarus suberosus Planch. (Connaraceae) leaves and evaluate its antihyperglycaemic, hypolipidaemic, antioxidant, and organ-protective effects in streptozotocin (STZ)-induced diabetic rats. METHODS An infusion-type aqueous extract was characterized by...

Aline Picolotto, Luís Fernando Paim, A. Donada et al. · Biomedicine & pharmacotherap... · 0 citations