Author

Marianna Skipitari

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Open access Jul 2026

Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation

It is shown that progerin leads to somatic mutation accumulation particularly in VSMCs, highlighting the need for early, cell-type-specific therapeutic intervention in HGPS to prevent permanent vascular tissue damage.

Lara G. Merino, Gwladys Revêchon, Santhilal Subhash et al. · Genome Medicine · 1 citation