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Marie-Josée Boucher

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Review Sep 2026

Abstract B041: MEK/ERK-dependent regulation of TFEB in response to chemotherapeutic stress

Our previous studies identified Transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, as highly expressed in pancreatic cancer (PDAC) cells, where it exhibits prominent nuclear localization even under basal conditions. Functional studies demonstrated that TFEB depletion in PDAC cel...

Marie-Josée Boucher, Marjorie Rolland · 0 citations

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