Abstract B041: MEK/ERK-dependent regulation of TFEB in response to chemotherapeutic stress
Our previous studies identified Transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, as highly expressed in pancreatic cancer (PDAC) cells, where it exhibits prominent nuclear localization even under basal conditions. Functional studies demonstrated that TFEB depletion in PDAC cel...