Open access
Aug 2026
CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage
This study demonstrates the integration of CRISPRa with single-cell technologies as a powerful platform for investigating and enriching iPSC-derived NCs, supporting future regenerative strategies across various fields.
Xiao-Le Tong, Marieke Visscher, F. Riemers et al.
· Stem Cell Reports · 0 citations