Natural Metabolites from Tabebuia aurea Reveal Isoform-Specific and Cooperative Modulation of Cathepsins B and L.
The development of isoform-selective inhibitors for homologous cysteine proteases remains challenging due to structural similarity and overlapping specificities. Metabolites isolated from Tabebuia aurea were investigated as modulators of Cathepsins B and L. Bioassay-guided fractionation yielded three compounds: 2,3-DH-...