Author

Marina Konopleva

2 papers indexed here

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Jul 2026

KRAS G12D Blocks Erythroid Differentiation and Promotes Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies 2251571

Genotyping of Transcriptomes is used to elucidate specific KRASG12D-driven pathways in preleukemic Clonal Hematopoiesis and 3 Acute Myeloid Leukemia patient samples and identify a novel quiescent CD83+ KRASG12D progenitor population in AML and demonstrate the therapeutic potential of MRTX1133 in vivo.

Leah Kravets, Ritesh Agarwal, Srinivas Aluri et al. · Journal of Immunology · 0 citations

Jul 2026

LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models.

Acute myeloid leukemia (AML) is an aggressive blood disorder characterized by rapid growth of poorly differentiated myeloid cells. Gain-of-function mutations in isocitrate dehydrogenases (IDHs) are detected in ~20% of AML and ~80% of secondary gliomas. Mutant IDH1/2 isoenzymes acquire neomorphic activity to produce 2-h...

Nathan A Brooks, Anna Skwarska, V. Salama et al. · Blood Cancer Discovery · 0 citations