Marina Pasca di Magliano

Abstract B087: Impact of RAS inhibition on T cell maturation in the PDAC microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer deaths in the United States with a dismal 5-year survival rate of 13%. More than 90% of pancreatic tumors are driven by oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS). Mutation-specific and pan-RAS inhibitors have s...