Nanoparticle Co-delivery of Microtubule Inhibitors and Cisplatin Overcomes DNA Repair-Mediated Resistance in Head and Neck Cancer.
Cisplatin remains a crucial chemotherapeutic for head and neck squamous cell carcinoma (HNSCC), but its effectiveness is limited by intrinsic or acquired resistance driven largely by enhanced DNA crosslink repair. Through a combined screen of DNA crosslink repair and cisplatin sensitivity modulators, our current study...