Open access
Sep 2026
Modifications of Lysine Residues 294 and 311 Within the Microtubule-Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria.
This study helps to establish a mechanistic framework linking combinatorial lysine modifications to Tau dysfunction and highlights the utility of region-resolved structural approaches to decipher posttranslational modification-dependent equilibria in intrinsically disordered proteins.
Dominik P. Vogl, Mario Migotti, R. Konrat et al.
· Angewandte Chemie · 0 citations