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Author

Mario Morales Martinez

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Jul 2026

Abstract A077: Multi-pathway inhibition and synergistic anticancer activity of novel biguanides in triple negative breast cancer models

A novel treatment based on the biguanide metformin structure, termed JD006, which significantly inhibits TNBC cell growth in vitro and in vivo in a dose-dependent manner and at lower doses than its parental metformin, provides a strong preclinical rationale for combining next-generation biguanides with CDK4/6 inhibitor...

Julie Liu, Mario Morales Martinez, Eduardo Mauricio Gonzalez et al. · 0 citations

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