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Maritta Räisänen

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Open access Jul 2026

Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion

It is demonstrated that a plastic cell state (PCS) is present already in polyps from patients with familial adenomatous polyposis and in mouse intestinal adenomas, in which PCS is associated with PROX1+ tumor stem cells.

Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone et al. · 0 citations