Open access
Oct 2026
Ubiquitin chain editing promotes p97/VCP-dependent removal of RPA from DNA.
DNA repair requires dynamic control of proteins on single-stranded DNA (ssDNA), yet how ubiquitin signaling regulates ssDNA-bound factors remains poorly understood. Here, we identify in human cells a ubiquitin chain-editing mechanism that promotes extraction of replication protein A (RPA) from ssDNA. We show that RPA s...
Matthew T. Drake, Xian-Zhen Zhou, Alexandra McStea et al.
· Molecules and Cells · 0 citations