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Author

Marjorie Rolland

2 papers indexed here

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Review Sep 2026

Abstract B041: MEK/ERK-dependent regulation of TFEB in response to chemotherapeutic stress

Our previous studies identified Transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, as highly expressed in pancreatic cancer (PDAC) cells, where it exhibits prominent nuclear localization even under basal conditions. Functional studies demonstrated that TFEB depletion in PDAC cel...

Marie-Josée Boucher, Marjorie Rolland · 0 citations
Open access Jul 2026

Msh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids.

Due to a rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is ensured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that specifically control their characteristics, i.e. self-renewal, multipotency and r...

Marjorie Rolland, Dominique Jean, M. Hamilton et al. · 0 citations

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