Author

Mark C. Wilkinson

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Open access Sep 2026

Screening the antimicrobial properties of snake venoms: an iterative fractionation approach

Abstract Antimicrobial resistance increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake venom has shown promise due to the complex mixture of proteins and peptides which demonstrate therapeutic utility in...

A. Fraser, Mark C. Wilkinson, Conor J. Meehan et al. · Access Microbiology · 0 citations

Open access Aug 2026

Disintegrin-like and Cysteine-rich Domains Govern Enzymatic Activity and Substrate Recognition in Echis Snake Venom Metalloproteinases

These findings establish accessory-domain-mediated substrate recognition as a key determinant of SVMP function, informing rational antivenom design and support a model in which PIII SVMP accessory domains enhance substrate positioning and catalytic efficiency while selectively restricting access to non-cognate substrat...

Sophie Hall, Bronwyn Rand, I. A. Cardoso et al. · bioRxiv · 0 citations