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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Markella Konstantinidou

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2 papers indexed here

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Open access Aug 2026

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

Molecular glues (MGs) stabilize protein-protein interactions (PPIs) through interactions at composite binding interfaces, thereby promoting cooperative ternary complex formation. For hub proteins that engage in multiple PPIs with widely varying intrinsic affinities, the interplay between binary PPI affinity and MG coop...

Marloes A. M. Pennings, Edmee M. F. Vandenboorn-Bönner, Lisa Nooren et al. · 0 citations
Open access Sep 2026

C-RAF Sequence-Encoded Cooperativity Hotspots for 14-3-3/C-RAF Molecular Glues

14-3-3 Proteins are hub proteins with an extensive interactome of phosphorylated client proteins, making them attractive targets for molecular glues (MGs) that stabilize specific 14-3-3/client protein complexes. However, selectively stabilizing individual 14-3-3 protein−protein interactions (PPIs) remains a key chall...

Marloes A. M. Pennings, G. Lauffer, Markella Konstantinidou et al. · 0 citations

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