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Marta Devodier

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Open access Sep 2026

Membrane Lipids and Water Shape the Unbinding Kinetics of ZM241385 from Human Adenosine A2A Receptor Variants

This work uncovers a solvent-mediated mechanism of ligand dissociation from an important pharmaceutical target, the adenosine receptor A2A, and identifies receptor–lipid interactions along the dissociation pathway as a potential target for rationally tuning drug kinetics.

Marta Devodier, Davide Mandelli, G. Rossetti et al. · 0 citations

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