Open access
Jul 2026
Encapsulated cell technology delivers ciliary neurotrophic factor to promote JAK/STAT-dependent photoreceptor survival in retinal degeneration
A therapeutic dose-response relationship linking NT-501–derived CNTF levels to JAK/STAT3 activation and photoreceptor protection in human retinal tissue is established, and an optimal concentration range for efficacy is suggested.
Yasuaki Iwama, Leia Laughlin, S. Harkins-Perry et al.
· bioRxiv · 0 citations